Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility

Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical to metastasis. Here, we show that vinculin null (vin(−/−)) cells and cells expressing a vinculin Y822F mutant have increased survival due to u...

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Bibliografiset tiedot
Päätekijät: Subauste, M. Cecilia, Pertz, Olivier, Adamson, Eileen D., Turner, Christopher E., Junger, Sachiko, Hahn, Klaus M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2004
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172187/
https://ncbi.nlm.nih.gov/pubmed/15138291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308011
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