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Proximal, selective, and dynamic interactions between integrin αIIbβ3 and protein tyrosine kinases in living cells

Stable platelet aggregation, adhesion, and spreading during hemostasis are promoted by outside-in αIIbβ3 signals that feature rapid activation of c-Src and Syk, delayed activation of FAK, and cytoskeletal reorganization. To evaluate these αIIbβ3–tyrosine kinase interactions at nanometer proximity in...

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Detalhes bibliográficos
Main Authors: de Virgilio, Maddalena, Kiosses, William B., Shattil, Sanford J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172182/
https://ncbi.nlm.nih.gov/pubmed/15123737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200402064
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