Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

Runx2 and phosphatidylinositol 3-kinase (PI3K)–Akt signaling play important roles in osteoblast and chondrocyte differentiation. We investigated the relationship between Runx2 and PI3K-Akt signaling. Forced expression of Runx2 enhanced osteoblastic differentiation of C3H10T1/2 and MC3T3-E1 cells and...

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Autors principals: Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, Ogita, Kiyokazu, Komori, Toshihisa
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172136/
https://ncbi.nlm.nih.gov/pubmed/15226309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200401138
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