p107 regulates neural precursor cells in the mammalian brain

Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. In vitro neurosphere assays revealed striking increases in the numb...

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Hlavní autoři: Vanderluit, Jacqueline L., Ferguson, Kerry L., Nikoletopoulou, Vassiliki, Parker, Maura, Ruzhynsky, Vladimir, Alexson, Tania, McNamara, Stephen M., Park, David S., Rudnicki, Michael, Slack, Ruth S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172121/
https://ncbi.nlm.nih.gov/pubmed/15353549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403156
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