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The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

Ubiquitin ligases of the Nedd4 family regulate membrane protein trafficking by modifying both cargo proteins and the transport machinery with ubiquitin. Here, we investigate the role of the yeast Nedd4 homologue, Rsp5, in protein sorting into vesicles that bud into the multivesicular endosome (MVE)...

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Bibliografski detalji
Glavni autori: Dunn, Rebecca, Klos, Deborah A., Adler, Adam S., Hicke, Linda
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172079/
https://ncbi.nlm.nih.gov/pubmed/15078904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200309026
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