Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C–related protein reveals a primordial role in subcellular sphingolipid distribution

Lipid movement between organelles is a critical component of eukaryotic membrane homeostasis. Niemann Pick type C (NP-C) disease is a fatal neurodegenerative disorder typified by lysosomal accumulation of cholesterol and sphingolipids. Expression of yeast NP-C–related gene 1 (NCR1), the orthologue o...

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Main Authors: Malathi, Krishnamurthy, Higaki, Katsumi, Tinkelenberg, Arthur H., Balderes, Dina A., Almanzar-Paramio, Dorca, Wilcox, Lisa J., Erdeniz, Naz, Redican, Francis, Padamsee, Mahajabeen, Liu, Ying, Khan, Sohail, Alcantara, Frederick, Carstea, Eugene D., Morris, Jill A., Sturley, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171978/
https://ncbi.nlm.nih.gov/pubmed/14970192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200310046
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