MCAK associates with the tips of polymerizing microtubules

MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells. Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-termin...

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Bibliographic Details
Main Authors: Moore, Ayana T., Rankin, Kathleen E., von Dassow, George, Peris, Leticia, Wagenbach, Michael, Ovechkina, Yulia, Andrieux, Annie, Job, Didier, Wordeman, Linda
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171944/
https://ncbi.nlm.nih.gov/pubmed/15883193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200411089
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