An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function

The mechanism by which the self-assembling GTPase dynamin functions in vesicle formation remains controversial. Point mutations in shibire, the Drosophila dynamin, cause temperature-sensitive (ts) defects in endocytosis. We show that the ts2 mutation, which occurs in the switch 2 region of dynamin&#...

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Hlavní autoři: Narayanan, Radhakrishnan, Leonard, Marilyn, Song, Byeong Doo, Schmid, Sandra L., Ramaswami, Mani
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2005
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171915/
https://ncbi.nlm.nih.gov/pubmed/15824135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200502042
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