Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial–mesenchymal transition

We report that the activity of glycogen synthase kinase-3 (GSK-3) is necessary for the maintenance of the epithelial architecture. Pharmacological inhibition of its activity or reducing its expression using small interfering RNAs in normal breast and skin epithelial cells results in a reduction of E...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bachelder, Robin E., Yoon, Sang-Oh, Franci, Clara, de Herreros, Antonio García, Mercurio, Arthur M.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2005
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171685/
https://ncbi.nlm.nih.gov/pubmed/15631989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409067
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