Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis

BACKGROUND: Intestinal fibrosis is characterized by abnormal production and deposition of extracellular matrix (ECM) proteins by activated myofibroblasts. The main progenitor cells of activated myofibroblasts are the fibroblasts and the epithelial cells, the latter through the epithelial-mesenchymal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Di Gregorio, Jacopo, Sferra, Roberta, Speca, Silvia, Vetuschi, Antonella, Dubuquoy, Caroline, Desreumaux, Pierre, Pompili, Simona, Cristiano, Loredana, Gaudio, Eugenio, Flati, Vincenzo, Latella, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313173/
https://ncbi.nlm.nih.gov/pubmed/28207769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171093
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