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BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo
Introducing mutations within the amyloid precursor protein (APP) that affect β- and γ-secretase cleavages results in amyloid plaque formation in vivo. However, the relationship between β-amyloid deposition and the subcellular site of Aβ production is unknown. To determine the effect of increasing β-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171598/ https://ncbi.nlm.nih.gov/pubmed/15642747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200407070 |
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