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Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

The Akt family of kinases are activated by growth factors and regulate pleiotropic cellular activities. In this study, we provide evidence for isoform-specific positive and negative roles for Akt1 and -2 in regulating growth factor–stimulated phenotypes in breast epithelial cells. Insulin-like growt...

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Detalhes bibliográficos
Main Authors: Irie, Hanna Y., Pearline, Rachel V., Grueneberg, Dorre, Hsia, Maximilian, Ravichandran, Preethi, Kothari, Nayantara, Natesan, Sridaran, Brugge, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171329/
https://ncbi.nlm.nih.gov/pubmed/16365168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505087
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