Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) in the ER, leading to activation of the unfolded protein response (UPR) and C/EBP homologous protein (CHOP)–induced apoptosis. Here w...

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Detalhes bibliográficos
Main Authors: DeVries-Seimon, Tracie, Li, Yankun, Yao, Pin Mei, Stone, Elizabeth, Wang, Yibin, Davis, Roger J., Flavell, Richard, Tabas, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171235/
https://ncbi.nlm.nih.gov/pubmed/16203857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200502078
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