Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy

Reactive oxygen species, in particular superoxide, have been closely linked to the underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates mechanoenergetic uncoupling of the myocyte but also adversely impacts on myocardial perfusion by depleting endothelial-derived nitric...

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Main Authors: Baldus, Stephan, Müllerleile, Kai, Chumley, Phil, Steven, Daniel, Rudolph, Volker, Lund, Gunnar K., Staude, Hans-Jürgen, Stork, Alexander, Köster, Ralf, Kähler, Jan, Weiss, Christian, Münzel, Thomas, Meinertz, Thomas, Freeman, Bruce A., Heitzer, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170896/
https://ncbi.nlm.nih.gov/pubmed/17015175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.07.010
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