Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum

BACKGROUND: HIV-1 Vpu targets newly synthesized CD4 receptor for rapid degradation by a process reminiscent of endoplasmic reticulum (ER)-associated protein degradation (ERAD). Vpu is thought to act as an adaptor protein, connecting CD4 to the ubiquitin (Ub)-proteasome degradative system through an...

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Detalhes bibliográficos
Main Authors: Binette, Julie, Dubé, Mathieu, Mercier, Johanne, Halawani, Dalia, Latterich, Martin, Cohen, Éric A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170451/
https://ncbi.nlm.nih.gov/pubmed/17937819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-75
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