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Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal

A 37 year woman developed neuroleptic induced parkinsonism that persisted long after the drug had been discontinued. This prompted a study of the effect of an eight week course of haloperidol (HAL) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats. Animals trea...

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Autors principals: Mazurek, M., Savedia, S., Bobba, R., Garside, S., Rosebush, P.
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170106/
https://ncbi.nlm.nih.gov/pubmed/9647315
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