Nitro-fatty Acid Reaction with Glutathione and Cysteine: KINETIC ANALYSIS OF THIOL ALKYLATION BY A MICHAEL ADDITION REACTION

Fatty acid nitration by nitric oxide-derived species yields electrophilic products that adduct protein thiols, inducing changes in protein function and distribution. Nitro-fatty acid adducts of protein and reduced glutathione (GSH) are detected in healthy human blood. Kinetic and mass spectrometric...

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Detalhes bibliográficos
Main Authors: Baker, Laura M. S., Baker, Paul R. S., Golin-Bisello, Franca, Schopfer, Francisco J., Fink, Mitchell, Woodcock, Steven R., Branchaud, Bruce P., Radi, Rafael, Freeman, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169496/
https://ncbi.nlm.nih.gov/pubmed/17720974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704085200
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