Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin α(IIb)β(3) Using a Reconstituted Mammalian Cell Expression Model

We have reconstituted the platelet glycoprotein (GP) Ib-IX–mediated activation of the integrin α(IIb)β(3) in a recombinant DNA expression model, and show that 14-3-3 is important in GPIb-IX signaling. CHO cells expressing α(IIb)β(3) adhere poorly to vWF. Cells expressing GPIb-IX adhere to vWF in the...

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Hauptverfasser: Gu, Minyi, Xi, Xiaodong, Englund, Graham D., Berndt, Michael C., Du, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1999
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169335/
https://ncbi.nlm.nih.gov/pubmed/10579727
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