Break-Induced Loss of Heterozygosity in Fission Yeast: Dual Roles for Homologous Recombination in Promoting Translocations and Preventing De Novo Telomere Addition

Loss of heterozygosity (LOH), a causal event in tumorigenesis, frequently encompasses multiple genetic loci and whole chromosome arms. However, the mechanisms leading to such extensive LOH are poorly understood. We investigated the mechanisms of DNA double-strand break (DSB)-induced extensive LOH by...

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Autors principals: Cullen, Jason K., Hussey, Sharon P., Walker, Carol, Prudden, John, Wee, Boon-Yu, Davé, Anoushka, Findlay, James S., Savory, Andrew P., Humphrey, Timothy C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169035/
https://ncbi.nlm.nih.gov/pubmed/17724078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00462-07
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