Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication

Human leukocyte antigen (HLA)-B27-positive subjects are uncommon in their ability to control infection with human immunodeficiency virus type 1 (HIV-1). However, late viral escape from a narrowly directed immunodominant Gag-specific CD8(+) T-lymphocyte (CTL) response has been linked to AIDS progress...

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Autori principali: Schneidewind, Arne, Brockman, Mark A., Yang, Ruifeng, Adam, Rahma I., Li, Bin, Le Gall, Sylvie, Rinaldo, Charles R., Craggs, Sharon L., Allgaier, Rachel L., Power, Karen A., Kuntzen, Thomas, Tung, Chang-Shung, LaBute, Montiago X., Mueller, Sandra M., Harrer, Thomas, McMichael, Andrew J., Goulder, Philip J. R., Aiken, Christopher, Brander, Christian, Kelleher, Anthony D., Allen, Todd M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2007
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169010/
https://ncbi.nlm.nih.gov/pubmed/17804494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01543-07
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