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Inhibition of Human Immunodeficiency Virus Type 1 Concerted Integration by Strand Transfer Inhibitors Which Recognize a Transient Structural Intermediate

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) inserts the viral DNA genome into host chromosomes. Here, by native agarose gel electrophoresis, using recombinant IN with a blunt-ended viral DNA substrate, we identified the synaptic complex (SC), a transient early intermediate in the inte...

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Main Authors: Pandey, Krishan K., Bera, Sibes, Zahm, Jacob, Vora, Ajaykumar, Stillmock, Kara, Hazuda, Daria, Grandgenett, Duane P.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169005/
https://ncbi.nlm.nih.gov/pubmed/17804497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02863-06
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