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Creation of RNA molecules that recognize the oxidative lesion 7,8-dihydro-8-hydroxy-2′-deoxyguanosine (8-oxodG) in DNA

We used in vitro evolution to obtain RNA molecules that specifically recognize and bind with high affinity to the oxidative lesion 7,8-dihydro-8-hydroxy-2′-deoxyguanosine (8-oxodG) in DNA. A pool of ≈10(15) RNA molecules containing a random insert of 45 nucleotides in length was subject to 10 succes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rink, Stacia M., Shen, Jiang-Cheng, Loeb, Lawrence A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1998
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC21690/
https://ncbi.nlm.nih.gov/pubmed/9751715
Tagiau: Ychwanegu Tag
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