A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques

A candidate vaccine (D1ME-VRP) expressing dengue virus type 1 premembrane and envelope proteins in a Venezuelan equine encephalitis (VEE) virus replicon particle (VRP) system was constructed and tested in conjunction with a plasmid DNA vaccine (D1ME-DNA) expressing identical dengue virus sequences....

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Detalhes bibliográficos
Main Authors: Chen, Lan, Ewing, Dan, Subramanian, Hemavathy, Block, Karla, Rayner, Jonathan, Alterson, Kimberly D., Sedegah, Martha, Hayes, Curtis, Porter, Kevin, Raviprakash, Kanakatte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168814/
https://ncbi.nlm.nih.gov/pubmed/17715224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00996-07
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