Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition

PspA is an important pneumococcal vaccine candidate that is capable of inducing protection in different animal models. Because of its structural diversity, a PspA-based vaccine should contain at least one fragment from each of the two major families (1 and 2) in order to elicit broader protection. I...

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Bibliographic Details
Main Authors: Darrieux, M., Miyaji, E. N., Ferreira, D. M., Lopes, L. M., Lopes, A. P. Y., Ren, B., Briles, D. E., Hollingshead, S. K., Leite, L. C. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168346/
https://ncbi.nlm.nih.gov/pubmed/17923518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00940-07
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