An Anti-β-Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo

In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-β-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of β-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds...

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Bibliografiske detaljer
Main Authors: Rachini, Anna, Pietrella, Donatella, Lupo, Patrizia, Torosantucci, Antonella, Chiani, Paola, Bromuro, Carla, Proietti, Carla, Bistoni, Francesco, Cassone, Antonio, Vecchiarelli, Anna
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168274/
https://ncbi.nlm.nih.gov/pubmed/17606600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00278-07
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