Pyrrolidine Dithiocarbamate and Diethyldithiocarbamate Are Active against Growing and Nongrowing Persister Mycobacterium tuberculosis

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 μg/ml and 0.13 μg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titer...

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Main Authors: Byrne, Sean T., Gu, Peihua, Zhou, Jiangbing, Denkin, Steven M., Chong, Curtis, Sullivan, David, Liu, Jun O., Zhang, Ying
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2007
Ábhair:
Experimental Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168016/
https://ncbi.nlm.nih.gov/pubmed/17876006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00753-07
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