Pharmacokinetics of Telbivudine in Subjects with Various Degrees of Renal Impairment

This study evaluates the effect of renal impairment on the pharmacokinetics of telbivudine. Thirty-six subjects were assigned, on the basis of creatinine clearance (CL(CR)), to 1 of 5 renal function groups with 6 to 8 subjects per group: normal renal function; mild, moderate, or severe renal impairm...

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Главные авторы: Zhou, Xiao-Jian, Swan, Suzanne, Smith, William B., Marbury, Thomas C., Dubuc-Patrick, Gloria, Chao, George C., Brown, Nathaniel A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2007
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167991/
https://ncbi.nlm.nih.gov/pubmed/17875994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00557-07
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