HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors

The envelope (Env) proteins of primate lentiviruses interact sequentially with CD4 and a coreceptor to infect cells. Changes in coreceptor use strongly influence viral tropism and pathogenesis. We followed the evolution of coreceptor use in pig-tailed macaques that developed severe CD4 T-cell loss d...

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Autores principales: Hoffman, Trevor L., Stephens, Edward B., Narayan, Opendra, Doms, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC21647/
https://ncbi.nlm.nih.gov/pubmed/9736741
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