Unexpected frameshifts from gene to expressed protein in a phage-displayed peptide library

A library of long peptides displayed on the pIII protein of filamentous phage was used in biopanning experiments against several protein targets. We find that a large percentage of phage clones that bind specifically to a target contain peptide-encoding genes that do not have an ORF. Instead, the re...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Cárcamo, Juan, Ravera, Mark W., Brissette, Renée, Dedova, Olga, Beasley, James R., Alam-Moghé, Ameena, Wan, Changhong, Blume, Arthur, Mandecki, Wlodek
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.19.11146
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