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Interaction of Spin-Labeled Inhibitors of the Vacuolar H(+)-ATPase with the Transmembrane V(o)-Sector

The osteoclast variant of the vacuolar H(+)-ATPase (V-ATPase) is a potential therapeutic target for combating the excessive bone resorption that is involved in osteoporosis. The most potent in a series of synthetic inhibitors based on 5-(5,6-dichloro-2-indolyl)-2-methoxy-2,4-pentadienamide (INDOL0)...

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Autors principals: Dixon, Neil, Páli, Tibor, Kee, Terence P., Ball, Stephen, Harrison, Michael A., Findlay, John B. C., Nyman, Jonas, Väänänen, Kalervo, Finbow, Malcolm E., Marsh, Derek
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157245/
https://ncbi.nlm.nih.gov/pubmed/17872954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.111781
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