The antisense bcl-2–IgH transcript is an optimal target for synthetic oligonucleotides

In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2–IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2–IgH mRNA in the antisense orientation, putatively responsible for the ove...

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Hlavní autoři: Morelli, Susanna, Delia, Domenico, Capaccioli, Sergio, Quattrone, Alessandro, Schiavone, Nicola, Bevilacqua, Anna, Tomasini, Silvia, Nicolin, Angelo
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21572/
https://ncbi.nlm.nih.gov/pubmed/9223330
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