Modified cytokeratins expressed on the surface of carcinoma cells undergo endocytosis upon binding of human monoclonal antibody and its recombinant Fab fragment

Previously, we have reported on successful imaging of colon, rectal, and pancreatic carcinomas in patients by using a radiolabeled all-human monoclonal antibody, COU-1, directed against modified cytokeratin. To further develop this antibody for use as an immunoconjugate, COU-1 was cloned by phage di...

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Detaylı Bibliyografya
Asıl Yazarlar: Ditzel, Henrik J., Garrigues, Ursula, Andersen, Claus B., Larsen, Morten K., Garrigues, H. Jacques, Svejgaard, Arne, Hellström, Ingegerd, Hellström, Karl Erik, Jensenius, Jens C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1997
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC21565/
https://ncbi.nlm.nih.gov/pubmed/9223323
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