Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment

The primary structures of the replicative DNA polymerases (gp43s) of bacteriophage T4 and its distant phylogenetic relative RB69 are diverged, retaining only 61% identity and 74% similarity. Nevertheless, RB69 gp43 substitutes effectively for T4 gp43 in T4 DNA replication in vivo. We show here that...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Dressman, Holly Kloos, Wang, Chien-Chia, Karam, Jim D., Drake, John W.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1997
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21553/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.15.8042
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