Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). In bacteria and Saccharomyces cerevisiae, this damaged base is excised by a DNA glycosylase with an associated lyase activity for chain cleavage. We have cloned, seque...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Roldán-Arjona, Teresa, Wei, Ying-Fei, Carter, Kenneth C., Klungland, Arne, Anselmino, Catherine, Wang, Rui-Ping, Augustus, Meena, Lindahl, Tomas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21548/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223306/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.15.8016
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