Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). In bacteria and Saccharomyces cerevisiae, this damaged base is excised by a DNA glycosylase with an associated lyase activity for chain cleavage. We have cloned, seque...

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Main Authors: Roldán-Arjona, Teresa, Wei, Ying-Fei, Carter, Kenneth C., Klungland, Arne, Anselmino, Catherine, Wang, Rui-Ping, Augustus, Meena, Lindahl, Tomas
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21548/
https://ncbi.nlm.nih.gov/pubmed/9223306
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