Mutations of HNF-1β inhibit epithelial morphogenesis through dysregulation of SOCS-3

Hepatocyte nuclear factor-1β (HNF-1β) is a Pit-1, Oct-1/2, Unc-86 (POU) homeodomain-containing transcription factor expressed in the kidney, liver, pancreas, and other epithelial organs. Mutations of HNF-1β cause maturity-onset diabetes of the young, type 5 (MODY5), which is characterized by early-o...

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Détails bibliographiques
Auteurs principaux: Ma, Zhendong, Gong, Yimei, Patel, Vishal, Karner, Courtney M., Fischer, Evelyne, Hiesberger, Thomas, Carroll, Thomas J., Pontoglio, Marco, Igarashi, Peter
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154440/
https://ncbi.nlm.nih.gov/pubmed/18077349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705957104
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