Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade

MEC-4 and MEC-10 are the pore-forming subunits of the sensory mechanotransduction complex that mediates touch sensation in Caenorhabditis elegans (O'Hagan, R., M. Chalfie, and M.B. Goodman. 2005. Nat. Neurosci. 8:43–50). They are members of a large family of ion channel proteins, collectively t...

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Hlavní autoři: Brown, Austin L., Fernandez-Illescas, Silvia M., Liao, Zhiwen, Goodman, Miriam B.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154353/
https://ncbi.nlm.nih.gov/pubmed/17261841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609672
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