Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

The invasion of human malignant melanoma cells into the extracellular matrix (ECM) involves the accumulation of proteases at sites of ECM degradation where activation of matrix metalloproteases (MMP) occurs. Here, we show that when membrane type 1 MMP (MT-MMP) was overexpressed in RPMI7951 human mel...

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Detalles Bibliográficos
Main Authors: Nakahara, Hirokazu, Howard, Linda, Thompson, Erik W., Sato, Hiroshi, Seiki, Motoharu, Yeh, Yunyun, Chen, Wen-Tien
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC21537/
https://ncbi.nlm.nih.gov/pubmed/9223295
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