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Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc

Transformation of cells in culture by polyoma virus requires integration of signals downstream of middle T–Shc and middle T-phosphatidylinositol 3-kinase interactions, but the same is not true for induction of tumors in the mouse. Thus, a middle T mutant defective in transformation and blocked in bi...

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Autors principals: Bronson, Roderick, Dawe, Clyde, Carroll, John, Benjamin, Thomas
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21536/
https://ncbi.nlm.nih.gov/pubmed/9223294
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