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Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IκBα
The NF-κB/Rel proteins are sequestered in the cytoplasm in association with IκBα. In response to external signals, IκBα is phosphorylated, multi-ubiquitinated, and degraded by proteasomes, thereby releasing NF-κB/Rel proteins to migrate to the nucleus. We have cloned a mouse ubiquitin-conjugating en...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21520/ https://ncbi.nlm.nih.gov/pubmed/9223278 |
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