Mode Switching Is the Major Mechanism of Ligand Regulation of InsP(3) Receptor Calcium Release Channels

The inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) plays a critical role in generation of complex Ca(2+) signals in many cell types. In patch clamp recordings of isolated nuclei from insect Sf9 cells, InsP(3)R channels were consistently detected with regulation by cytoplasmic InsP(3) and...

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Главные авторы: Ionescu, Lucian, White, Carl, Cheung, King-Ho, Shuai, Jianwei, Parker, Ian, Pearson, John E., Foskett, J. Kevin, Mak, Don-On Daniel
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151663/
https://ncbi.nlm.nih.gov/pubmed/17998395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709859
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