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Electrostatic Interaction of Internal Mg(2+) with Membrane PIP(2) Seen with KCNQ K(+) Channels
Activity of KCNQ (Kv7) channels requires binding of phosphatidylinositol 4,5-bisphosphate (PIP(2)) from the plasma membrane. We give evidence that Mg(2+) and polyamines weaken the KCNQ channel–phospholipid interaction. Lowering internal Mg(2+) augmented inward and outward KCNQ currents symmetrically...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151647/ https://ncbi.nlm.nih.gov/pubmed/17724161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709821 |
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