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Muscle Chloride Channel Dysfunction in Two Mouse Models of Myotonic Dystrophy

Muscle degeneration and myotonia are clinical hallmarks of myotonic dystrophy type 1 (DM1), a multisystemic disorder caused by a CTG repeat expansion in the 3′ untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. Transgenic mice engineered to express mRNA with expanded (CUG)(250...

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Hlavní autoři: Lueck, John D., Mankodi, Ami, Swanson, Maurice S., Thornton, Charles A., Dirksen, Robert T.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151606/
https://ncbi.nlm.nih.gov/pubmed/17158949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609635
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