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A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels

Open-channel blockers such as tetraethylammonium (TEA) have a long history as probes of the permeation pathway of ion channels. High affinity blockade by extracellular TEA requires the presence of an aromatic amino acid at a position that sits at the external entrance of the permeation pathway (resi...

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Autors principals: Ahern, Christopher A., Eastwood, Amy L., Lester, Henry A., Dougherty, Dennis A., Horn, Richard
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151593/
https://ncbi.nlm.nih.gov/pubmed/17130518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609654
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