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Reversal of HCN Channel Voltage Dependence via Bridging of the S4–S5 Linker and Post-S6
Voltage-gated ion channels possess charged domains that move in response to changes in transmembrane voltage. How this movement is transduced into gating of the channel pore is largely unknown. Here we show directly that two functionally important regions of the spHCN1 pacemaker channel, the S4–S5 l...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151568/ https://ncbi.nlm.nih.gov/pubmed/16908727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609590 |
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