Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

Transcriptional initiation is a key step in the control of mRNA synthesis and is intimately related to chromatin structure and histone modification. Here, we show that the ubiquitylation of H2A (ubH2A) correlates with silent chromatin and regulates transcriptional initiation. The levels of ubH2A var...

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Detalhes bibliográficos
Main Authors: Nakagawa, Takeya, Kajitani, Takuya, Togo, Shinji, Masuko, Norio, Ohdan, Hideki, Hishikawa, Yoshitaka, Koji, Takehiko, Matsuyama, Toshifumi, Ikura, Tsuyoshi, Muramatsu, Masami, Ito, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151013/
https://ncbi.nlm.nih.gov/pubmed/18172164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1609708
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