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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
Integrin-mediated adhesion promotes cell survival in vitro, whereas integrin antagonists induce apoptosis of adherent cells in vivo. Here, we demonstrate that cells adherent within a three-dimensional extracellular matrix undergo apoptosis due to expression of unligated integrins, the β subunit cyto...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2150834/ https://ncbi.nlm.nih.gov/pubmed/11684710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200106070 |
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