Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturation is unknown. Using chimeric fluorescent proteins encoding tandem FYVE domains, we found that phosphatid...

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Main Authors: Vieira, Otilia V., Botelho, Roberto J., Rameh, Lucia, Brachmann, Saskia M., Matsuo, Tsuyoshi, Davidson, Howard W., Schreiber, Alan, Backer, Jonathan M., Cantley, Lewis C., Grinstein, Sergio
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150784/
https://ncbi.nlm.nih.gov/pubmed/11581283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200107069
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