Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo

The docking protein Gab1 binds phosphorylated c-Met receptor tyrosine kinase directly and mediates signals of c-Met in cell culture. Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional analysis of Gab1 by targeted mutagenesis in the...

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Bibliographic Details
Main Authors: Sachs, Martin, Brohmann, Henning, Zechner, Dietmar, Müller, Thomas, Hülsken, Jörg, Walther, Ingrid, Schaeper, Ute, Birchmeier, Carmen, Birchmeier, Walter
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150711/
https://ncbi.nlm.nih.gov/pubmed/10995442
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