An identical novel mutation in BRCA1 and a common haplotype in familial ovarian cancer in non-Ashkenazi Jews.

Unique germline mutations in BRCA1 and BRCA2 account for inherited predisposition to breast and ovarian cancer in high-risk families. In Jewish high-risk individuals of Ashkenazi (east European) descent, three predominant mutations, 185delAG and 5382insC (BRCA1) and 6174delT (BRCA2), seem to account...

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Hauptverfasser: Theodor, L., Bar-Sade, R., Kruglikova, A., Ben-Baruch, G., Risel, S., Shiri-Sverdlov, R., Hirsh Yechezkel, G., Modan, B., Papa, M. Z., Rechavi, G., Friedman, E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1998
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150352/
https://ncbi.nlm.nih.gov/pubmed/9667663
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